Leading ANCA Test Kit Factory - High Quality Associated Vasculitis Diagnosis

Chemiluminescent Solution（Autoimmune Diseases）
Series	Product Name	Abbr
ANCA - Associated Vasculitis	Anti-Myeloperoxidase Antibody	MPO
	Anti-Proteinase 3 Antibody	PR3
	Anti-Glomerular Basement Membrane Antibody	GBM
	Anti-Endothelial Cell Antibody	AECA IgG
	Bactericidal/Permeability Increasing Protein	BPI
	Protease 3	PR3-Ⅱ
	Myeloperoxidase	MPO-Ⅱ

Myeloperoxidase (MPO) is a heme protein mainly found in neutrophils, monocytes and macrophages. Synthesized within the bone marrow before entry into circulation by granulocytes and stored within azurophagic granules. MPO has the effect of promoting inflammation and atherosclerosis. It can affect the stability of atherosclerotic plaques and cause acutecoronarysyndrome (ACS) by increasing oxidative stress. MPO is considered to be one of the systemic markers of inflammation and a marker of neutrophil activation. MPO participates in the whole process of atherosclerosis deterioration, occurrence and development through various ways. Proteinase 3 is the cytoplasmic target antigen of ANCA, hydrolyzing elastase, IV collagen fiber or other components. PR3 positive is common in cardiovascular diseases, and is closely related to active granulomatous vasculitis (GPA), with a sensitivity of 85%. The sensitivity of PR3 to GPA depends on the activity of the disease and the stage of the disease. PR3 can activate neutrophils to cause degranulation reaction, activate a large number of proteolytic enzymes, and cooperate with other immune mediators to cause vascular inflammation. Anti-glomerular basement membrane antibody is a serological indicator for all anti-GBM glomerulonephritis including Goodpasture’s syndrome.A few cases is suffer from mild mesangial proliferative nephritis which can keep normal renal function. Pulmonary involvement is manifested as pulmonary hemorrhage, or massive hemoptysis which may cause life-threatening suffocation. A small amount of alveolar hemorrhage happened, not reach the bronchus but absorbed in the alveoli, presenting as subclinical pulmonary hemorrhage. The antigen of anti-endothelial cell antibody (AECA) is a cluster of heterogeneous proteins located on the surface of endothelial cells. This antibody can appear in a variety of autoimmune diseases associated with vasculitis. Clinically, it is mainly used for auxiliary diagnosis of primary, secondary autoimmune vasculitis, idiopathic renal vasculitis, systematic lupus erythematosus (SLE), APS, RA associated vasculitis, mixed connective tissue disease and primary Sjogren's syndrome, but this test can not be used as a diagnostic or exclusive criterion for disease alone.

ANCA - Associated Vasculitis Test Kit

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