Anemia Chemiluminescense Immunoassay Kit

Pernicious anemia (PA) is a disease in which there are not enough red blood cells partially due to autoimmune problems or lack of vitamin B12. The most common initial symptom is feeling tired. Other symptoms may include shortness of breath, pale skin, chest pain, numbness in the hands and feet, poor balance, a smooth, red tongue, poor reflexes, and confusion.
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Products Details

Series

Product Name

Abbr

Acute Anemia

Anti-parietal Cell Antibody

PCA

Anti-intrinsic factor Antibody

IF
Pernicious anemia (PA) is a disease in which there are not enough red blood cells partially due to autoimmune problems or lack of vitamin B12. The most common initial symptom is feeling tired. Other symptoms may include shortness of breath, pale skin, chest pain, numbness in the hands and feet, poor balance, a smooth, red tongue, poor reflexes, and confusion. If treatment is not provided, some of these problems may become permanent. Parietal cell antibodies are found in other autoimmune disorders and also in up to 10% of healthy individuals, making the test nonspecific. However, around 85% of PA patients have parietal cell antibodies, which means they are a sensitive marker for the disease. 3 The combination of both tests of intrinsic factor antibodies and parietal cell antibodies may improve the overall sensitivity and specificity of the diagnostic results. 7 About 90% of individuals with PA have antibodies for parietal cells; however, only 50% of all individuals in the general population with these antibodies have pernicious anemia. The most common initial symptom of PA is feeling tired. Other symptoms may include shortness of breath, pale skin, chest pain, numbness in the hands and feet, poor balance, a smooth, red tongue, poor reflexes, and confusion. When it is suspected, diagnosis is often made by testing antibodies to intrinsic factor. The presence of antibodies to gastric parietal cells and intrinsic factors is common in PA. Intrinsic factor antibodies are much less sensitive than parietal cell antibodies, but they are much more specific. They are found in about half of PA patients and are very rarely found in other disorders. These antibody tests can distinguish between PA and food-B12 malabsorption. The combination of both tests of intrinsic factor antibodies and parietal cell antibodies may improve the overall sensitivity and specificity of the diagnostic results.

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