Anti-phospholipid Antibody Profile Test Kit

The antiphospholipid syndrome is the collective term for the clinical signs caused by anti-phospholipid antibody (APL), mainly include thrombophilia, recurrent spontaneous abortion (RSA) and thrombocytopenia. Anti phosphatidylethanolamine antibody plays a physiological role by binding to phosphatidylethanolamine binding proteins.
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Chemiluminescent Solution（Autoimmune Diseases）

Series

Product Name

Abbr

Anti-phospholipid Antibody Profile

Anti-phosphatidylethanolamine IgG

aPE-IgG

Anti-beta Glycoprotein Domain 1

β2-GP1-Domain 1

Anti-vimentin

VIM

Anti-annexin A2

ANXA2

Anti-annexin A5

ANXA5

Anti-Tenascin-C

TN-C

Anti-Tenascin-S

TN-S
aPE-IgG further affects thrombosis and coagulation function by affecting the kallikrein kininogen kinin system. Annexin A2 is a calcium dependent phospholipid binding protein and a co receptor for tissue-type plasminogen activator (tPA) and it plays an important role in maintaining blood flow and preventing thrombosis in blood vessels. Anti-β2 GP1-Domain 1 antibody competes with annexin A5 for binding to negatively charged phospholipid molecules, disrupts the protective sheath membrane formed by annexin A5, and impedes its anticoagulant function. Vimentin (VIM), an important type III intermediate filament protein. Anti VIM antibody can be used as a diagnostic index for APS diagnosis. Annexin A2 is a 36KD calcium-dependent phospholipid binding protein. As a key receptor molecule in the coagulation-anticoagulation-fibrinolysis network. The positive rate of anti-ANXA2 antibody in PATIENTS with APS and SLE with thrombi was significantly higher than that in patients with SLE without thrombi and healthy subjects. ANXA2 was significantly associated with thrombosis/morbidities, contributing to potential APS cases. Annexin A5 is a potent anticoagulant protein mainly found in trophoblasts and vascular endothelial cells. By binding to negatively charged phospholipids, annexin A5 undergoes oligomerization to form a protective barrier against thrombin. Anti β2 GP1 dependent antiphospholipid antibody promoted thrombus formation by interfering with efficient binding of annexin A5 to endothelial cells. Protein C is a vitamin K-dependent protein that circulates in the blood. It is activated under the action of thrombin to form activated protein C which acts on coagulation, fibrinolysis and other systems to exert anticoagulant effect. Protein S, a vitamin K-dependent nonenzymatic plasma protein synthesized in the liver, is a cofactor of activated protein C anticoagulation. APCR has a close relationship with thrombus formation and RAS, so the detection of anti protein S antibody and anti protein C antibody is of great clinical significance.  

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