Factory Direct: Accurate Antiphospholipid Syndrome(APS) Test Kit

Chemiluminescent Solution（Autoimmune Diseases）
Series	Product Name	Abbr
Antiphospholipid Syndrome	Anti-Cardiolipin IgM	aCL-IgM
	Anti-Cardiolipin IgA	aCL-IgA
	Anti-Cardiolipin IgG	aCL-IgG
	Anti-Cardiolipin IgM/A/G	aCL-IgM/A/G
	Anti-β2 Glycoprotein 1 IgM	β2-GP1-IgM
	Anti-β2 Glycoprotein 1 IgA	β2-GP1-IgA
	Anti-β2 Glycoprotein 1 IgG	β2-GP1-IgG
	Anti-β2 Glycoprotein 1 IgM/A/G	β2-GP1-IgM/A/G
	Anti-Phosphatidylserine/Prothrombin IgG	aPS/PT IgG
	Anti-Phosphatidylserine/Prothrombin IgM	aPS/PT IgM

Anti-cardiolipin antibody (aCL) is an autoantibody that targets negatively charged cardiolipin on platelet and endothelial cell membranes. aCL is a type of anti-phospholipid antibody and a hallmark of anti-phospholipid syndrome (APS). Its determination can help for the auxiliary diagnosis of habitual abortion, thrombosis, thrombocytopenia and lupus encephalopathy. aCL has a high positive detection rate in SLE patients. The incidence of vasculitis, hemolytic anemia, or central nervous system in aCL antibody positive SLE patients is significantly higher than that of aCL antibody negative SLE patients. SLE women with aCL antibody positive are more likely to form thrombus due to enhanced platelet agglutination function and increased thrombus, and are prone to abortion during pregnancy. The detection of aCL antibody in serum and cerebrospinal fluid is helpful for the clinical diagnosis of patients with neuropsychiatric lupus. The positive rate of aCL antibody is 33-49% in RA patients, among which 42-59% in juvenile RA patients. When phospholipids have been secreted outside the cell membrane and combined with the serum 2-glycoprotein-1, the antigenic sites are exposed and the corresponding autoantibodies are induced, which is called β2 glycoprotein 1 antibody. The normal range of β2 glycoprotein 1 antibodies in serum is 0-20 RU/mL. The higher concentration is mainly seen in patients with antiphospholipid antibody syndrome (with the sensitivity of 30-60%, and specificity of 98%) and patients with systemic lupus erythematosus (SLE). Simultaneous determination of β2 glycoprotein 1 and aCL results in a 95% diagnostic rate of anti-phospholipid antibody syndrome (APS). Besides, the higher concentration of β2 glycoprotein 1 can also be seen in habitual abortion, rheumatoid arthritis, Kawasaki disease, etc. Anti-phosphatidylserine /prothrombin antibody (aPS/PT) has diagnostic value in aPS and risk assessment of thrombus. Some domestic scholars reported that 56.9% APS /PT positive patients with acL-negative APS and 60.5% APS /PT positive patients with A β2-GPI. In addition, the aPS/PT assay is not affected by anticoagulants and can be used as a potential replacement indicator for lupus anticoagulants (LAC) in clinically suspected aPS patients with established or difficult anticoagulant therapy.

Antiphospholipid Syndrome(APS) Test Kit

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