Rheumatoid Arthritis(RA) Test Kit

Rheumatoid arthritis is a systemic inflammatory disorder that mainly affects the diarthrodial joint. It is the most common form of inflammatory arthritis, and has a substantial societal effect in terms of cost, disability, and lost productivity.
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Products Details

Chemiluminescent Solution（Autoimmune Diseases）

Series

Product Name

Abbr

Rheumatoid Arthritis

Rheumatoid Factor IgM

RF-IgM

Rheumatoid Factor IgA

RF-IgA

Rheumatoid Factor IgG

RF-IgG

Rheumatoid Factor IgM/A/G

RF-IgM/A/G

Anti-RA33 Antibody

RA33

Anti-Cyclic Citrullinated Peptide Antibody

CCP

Anti-Mutated Citrullinated Vimentin Antibody

MCV

Anti-Matrix Metalloproteinase 3 Antibody

MMP-3
Rheumatoid factor (RF) is an antibody against the epitope of human or animal IgG molecule Fc fragments. It is an autoantibody targeting the antigen of denatured IgG. The content of RF IgM is not closely related to the activity of rheumatoid arthritis. IgG type is closely related to synovitis, vasculitis and extra-articular symptoms of rheumatoid arthritis patients. IgA type more often happens in rheumatoid arthritis, scleroderma, etc. Anti-RA33 antibody is with high specificity up to 92% for the diagnosis of rheumatoid arthritis (RA). Anti-RA33 antibody may appear in the early stage of RA, which is suitable for disease screening. It is an effective serological indicator, especially when atypical RA (RF-negative) occurs. The detection of anti-cyclic citrullinated peptide antibody (anti-CCP) is highly specific for the diagnosis of rheumatoid arthritis and can be used for its early diagnosis. Anti-CCP antibody is not only an indicator of early diagnosis of RA, but also a sensitive indicator to distinguish invasive and non-invasive RA. Antibody-positive patients are more likely to develop severe bone destruction of joints than antibody-negative patients. Anti-Mutated Citrullinated Vimentin Antibody (anti-MCV) has a specificity of 80-97% of rheumatoid, sensitivity is around 44.8-85.0%. In the very early stages of the disease, anti-MCV can be positive, and has a very high positive predicted value. Matrix metalloproteinase 3 (MMP-3) promotes the metastasis of cancer cells by directly degrading extracellular matrix and basement membrane components, regulating the adhesion of tumor cells and matrix, activating proteins with potential activity. A unique feature of MMP-3 is, it can activate other types of MMPs, or shear core proteoglycan matrix molecules and release transforming growth factor-β(TGF-β) with certain biological activities, regulating tumor angiogenesis, also have certain effect to promote tumor cell proliferation.

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