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Thrombocytopenic Purpura Test Kit

Anti-platelet antibody (APA) is an autoantibody against autologous platelet glycoprotein produced by the disorder of the body’s immune function, which can lead to the destruction of platelets. Immune thrombocytopenic purpura (ITP) is an autoimmune disease that accelerates platelet damage and inhibits platelet production. APA mediated platelet destruction and / or cytotoxic T cell lysis is an important cause of the increase of platelet destruction.

Chemiluminescent Solution（Autoimmune Diseases）
Series	Product Name	Abbr
Thrombocytopenic Purpura	Anti-Platelet Antibody	APA IgG

Anti-platelet antibody (APA) is an autoantibody against autologous platelet glycoprotein produced by the disorder of the body's immune function, which can lead to the destruction of platelets. Immune thrombocytopenic purpura (ITP) is an autoimmune disease that accelerates platelet damage and inhibits platelet production. APA mediated platelet destruction and / or cytotoxic T cell lysis is an important cause of the increase of platelet destruction. APA can occur in ITP or in patients with systematic lupus erythematosus (SLE). The presence or absence of SLE might modify the clinical or serological expression of APS. Apart from the classical manifestations, APS patients with associated SLE more frequently display a clinical profile with arthralgias, arthritis, autoimmune hemolytic anemia, livedo reticularis, epilepsy, glomerular thrombosis, and myocardial infarction. In high risk situations, such as surgery, prolonged immobilization, and puerperium, the prophylaxis should be potentiated with low molecular weight heparin. Sixteen percent of SLE patients present with ITP 10 years before the remaining clinical manifestations of lupus appear, and approximately 3% to 5% of ITP develop SLE. Related data show that APA plays a significant role in thrombocytopenia. Neonatal thrombocytopenic purpura (NTP) results from a combination of thrombocytopenia and (or) exacerbated platelet destruction with clinically visible generalized petechiae, ecchymoses on the skin and, in severe cases, gastrointestinal and intracranial hemorrhages, NTP has been classified as immunological, infectious, congenital or genetic, with 10% due to syngeneic or passive immunological factors. Pseudothrombocytopenia (EDP) is mainly a thrombocytopenic phenomenon due to anticoagulant factors. Because of some anticoagulants (such as EDTA) induce agglutination of platelets by special proteins in the platelet, agglutinated platelets cannot be counted by the hematology analyzer when tested on a fully automated hemocytometer, thus resulting in a spurious decrease in the platelet count present in the normal range. In some cases, pseudothrombocytopenia conceals thrombocytopenia or thrombocytosis, which may occur in health or illness.

Thrombocytopenic Purpura Test Kit

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